On April 26, 2008, Sheila E., along with Morris Day and Jerome Benton, performed with Prince at the Coachella Music Festival. From May 2 to 6, 2008, Sheila E. played four sold-out shows at Blue Note Tokyo, the most frequented jazz music club in Tokyo, Japan.
In 2016, Sheila provided drums for Hans Zimmer and Junkie XL‘s orchestral soundtrack to the blockbuster superhero films Man of Steel and Batman v Superman: Dawn of Justice. On June 26, 2016, Sheila and The New Power Generation led a tribute to Prince on the 2016 BET Awards, featuring a medley of his hits.
The next day, she released a new song, “Girl Meets Boy,” in honor of Prince.