The Red Key item is required to access it, but it shows the direction to get there, UNLOCK: Unlock this item by defeating The Beast as Eve, Upon entering each new floor, if you have one red heart or less, another one is added, This effect works while moving up floors in the backwards path, This item has no effect for characters with non-red health i.e. Bethany was added in Repentance, the latest DLC. While Isaac is great, doubly so when you get the D6, every character has their own unlocks tied to their progression which benefits you regardless of who you select on the next run, so they're worth taking for a spin. The recharge time of this item depends on the Rune/Soul Stone held: 2 rooms: Rune of Ansuz, Rune of Berkano, Rune of Hagalaz, Soul of Cain, 3 rooms: Rune of Algiz, Blank Rune, Soul of Magdalene, Soul of Judas, Soul of ?? Beyond the womb floor, replaces all coin and key spawns with a random pickup as follows: Bomb - 26.6% chance. Heres how to unlock each tainted character and what makes them special. - Gives the curse of the maze effect for the current floor. Tainted Samson:Has a similarBerserk effect to regular Samson, but it restricts him to a powerful melee weapon and also has a timer that refills as he kills enemies. Like Isaac, he starts with three red hearts but, if you take damage, you'll start to get redder as you deal more damage yourself. No longer drops black hearts like it used to. She's Lazarus' sister, hence the unlock parameters. The Binding Of Isaac: How To Become Guppy, The Binding Of Isaac Rebirth: How To Unlock All 22 Endings, The Binding Of Isaac: Ranking All Of The Planetarium Items, Game-Breaking Synergies In The Binding Of Isaac, Stardew Valley: Every Golden Walnut Location And How to Get Them, Stardew Valley: The Best Fish For Fish Ponds, Stardew Valley: The Best Professions To Pick For Every Skill. Placing a bomb while pressing a fire button will fire an explosive rocket in that direction, Placing a bomb while standing still will place a regular bomb, Upon use, spawns a flame familiar that fires spectral tears and deals contact damage to enemies. pedestal items, Picking up all dropped items leaves you with the same health and consumables you had before, This allows you to manipulate your consumables in lots of different ways, for example by rerolling them with the D6/D20, re-arrange your Bone heart containers and more, If you have the Tarot Cloth item, this card will also drop all your passive items on the floor as pedestals, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Lost, Gives you a blue aura that repels enemy projectiles, causing them to slowly curve away from Isaac and avoid hitting him, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Judas, Causes Mom's Foot to keep stomping down randomly for 60 seconds where Isaac is standing, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Lilith, Gives 2 HP Up and +1.5 Tears Up for 60 seconds, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Eve, Teleports you to an extra boss room, that drops a Boss room item as normal. For example, an item which usually gives +1 Damage would instead give a small 'all stats up', Stats effected by this item are: Damage, Tears, Range, Speed, When taken with another item which gives an extreme value in a certain stat (e.g. The mirrored floor rooms have respawned enemies, and allows you to optionally fight the Boss a second time for an extra item, When combined with Knife Piece 2, can be used to stab the fleshy door in the Mausoleum II, which then leads to the Corpse floor and the Mother boss, Combine with Knife Piece 1 to create a Knife which can be fired across the room, dealing 25 damage to any enemies it comes into contact with, In the Mines/Ashpit II, there's a room with a minecart and a broken track. Stat Up becomes Stat Down), Any 'Stat down' pills you take give you a permanent +0.6 Damage Up (Horse pills +1.2), Most other pills spawn a black heart when used, including R U A Wizard?, Amnesia, Bad Trip, ?? Collect all non-DLC items in the game, unlock all of the secrets and endings The Binding of Isaac Repentance Home stage, Taking Dad's Note in The Binding of Isaac Repentance, Finding the Red Key in The Binding of Isaac Repentance, The Binding Of Isaac: Repentance - How To Unlock Tainted Characters, The Binding Of Isaac: A Guide To Every Character And How To Unlock Them, The Binding Of Isaac: Every Dice Room And What They Do, Coral Island: Best Romanceable Characters, Ranked, The 14 Best Idle Games For iPhone And Android, 12 Things We Wish We Knew Before Starting The Mortuary Assistant, Stardew Valley: How to Complete The Pirates Wife Quest, Stardew Valley: The Best Fruits For Wine (And How To Get Them). PAC1; F1SM To get to this floor you need the Dads Note item. Counts as 1 of 3 angel items needed towards the Seraphim transformation. Pearls are one of the valuable items in the game that players can get by playing as Abdullah (an Arab Character). (Does not roll your devil deal items), 5 Dot - Reroll and restart the current floor (Forget Me Now effect), 6 Dot - Reroll all of your items and all the pickups on the entire floor (Combined 1 + 3 + 4 rooms), The same order as the in-game collection page. This tear turns enemies to gold for a few seconds and causes them to drop 1-4 coins if killed while golden (similar to the Midas' Touch item), When the Midas Touch tear effect triggers, it will remove 1 coin from your current total, The golden tear deals double your tear damage, The effect can still trigger even if you have no held coins, UNLOCK: Unlock this item by defeating Greedier Mode with Keeper, Doubles the effect of most tarot cards. Breakfast = +0.2 shot speed, +1.5 Range. After a minute or so of not hurting her she will fly away and spawn Plum Flute, UNLOCK: Unlock this item by allowing Baby Plum to escape instead of killing her, Spawns a star with a white aura around it, that floats very slowly through each room on the floor, making its way towards the boss room, While standing inside the aura, you gain a big Tears Up (x2.5 fire rate), Damage Up (damage * 1.2 + 1) and homing tears, The star continues to make its way through the floor, even if you aren't in the same room as it, moving faster if you are a long distance ahead of it, On The Void floor, it will move towards the boss room containing Delirium, Doesn't travel into the Hush or Mega Satan boss room, It may travel through secret/curse rooms on its route to the boss room, Counts as 1 of 3 astrology items needed in the same run to unlock Planetariums, UNLOCK: Unlock this item by defeating Delirium as Bethany, Gives you a baby in an ice cube, which can be kicked around the room by walking into it, Enemies take damage from Cube Baby depending on how fast it was travelling when it hit them. You can also upgrade Cain. This one will be a hidden question mark, Allows you to see what both items are on alternative path floors (Downpour/Dross, Mines/Ashpit, Gehenna/Mausoleum), UNLOCK: Unlock this trinket by defeating challenge #40 (Seeing Double). Function: Spending money gives out random stat boosts, Unlock Condition: Defeat Mother as Keeper. *, stone, rock, grey, gray, white, dice, pip, broken, die, While held this trinket causes all pickups and enemies to move slowly towards you, Will also attract the Mom's Foot and Ultra Greed door entities, *, white, grey, gray, pill, medicine, drug, Randomly Isaac will gain a camouflage for a few seconds and all enemies in the current room will have a confused status effect applied to them, This trinket can be used to open the door to Mausoleum in Depths II, Gives a small chance to spawn a friendly attack spider while in a hostile room with enemies, Leaves a pool of green creep under all bombs you place, which damages enemies that walk over it, *, green, bogey, snot, ocarina, bobs bladder, bob bladder, Gives a +6.66% chance of a getting a small battery after clearing a room, Gives a +2.0% chance for pickups to be small batteries, Gives a +5.0% chance to add an extra charge to your active item after clearing a room, *, metal, grey, gray, silver, pill, cross, Exploding bombs now have a chance to drop another bomb that you can pick up, Higher chance to find crawl spaces when exploding rocks, UNLOCK: Unlock this trinket by beating Challenge #27 (Brains), *, toe, finger, thumb, grey, gray, black, red, yellow, Gives a different trinket effect per room, randomly choosing between any of the other available trinkets in the game. spray, brown, white, yellow, moms purfume, Tears can now be charged and released in a shotgun style effect, much like Monstro's main attack, Partial charging does nothing - must be fully charged to use, * item room, treasure room, item room pool, pink, body part, monstros lung, On pickup Abaddon converts all your heart containers to black hearts, then gives you +2 more black hearts, Tears now have a chance to induce the fear effect, causing enemies to run away from Isaac for a short period, REPENTANCE - No longer kills Keeper when picked up, just reduces coin health to 1, UNLOCK: Unlock this item by beating the Chest with Azazel, * devil pool, devil room pool, devil deal, red devil sign, abandon, abadon, pentagram, Isaac leaves a trail of tar behind him which will slow down enemies that walk over it, Tears have a chance to slow enemies and their projectiles for a short period of time, The chance to slow enemies can improve based on your luck stat and will always slow enemies at +18 Luck, * item room, treasure room, item room pool, black, grey, gray, The Stop Watch applies a permanent but slight slowing effect to all enemies and their projectiles, The slowing effect has a reduced effect against Brimstone lasers fired by enemies, REPENTANCE - Stop Watch now slows down all enemies in the game once again, but the slow effect is much less drastic. A Radioactive Spider: Defeat Boss in Basement 2. Clots returning back to Eve deal 3x damage as they suck back in, The type of heart consumed to create a clot will give it different abilities: Soul Hearts = More health, Black Hearts = Dark Matter effect, Eternal Hearts = Sacred Heart effect, Gold Hearts = Midas Touch effect, Bone Hearts = Compound Fracture effect, Rotten Hearts = Less health, Tainted Eve starts with this item, but can be used by any character after unlocking it and finding it in the item room, UNLOCK: This item comes along with Tainted Eve. * shop room pool, shop item pool, the lost item pool, white, Causes Isaac's head to detach and orbit his body, blocking shots and dealing 7 contact damage per tick, BFFs will cause the Guillotine head to do double damage (14 damage per tick), Tears are still fired from Isaac's head but the hitbox remains around his body, UNLOCK: Unlock this item by beating the Isaac boss with Judas, * item room, treasure room, item room pool, chop, head, silver, metal, Gives Isaac an orbital ball of bandages that deals 7 contact damage per tick and blocks enemy shots, Collecting a second Ball of Bandages in the run turns the orbital into a pink head that shoots tears that deal 7 damage each and have a chance to charm enemies, Getting a third Ball of Bandages will transform the head into bandage girl which will chase enemies dealing 3.5 contact damage per tick while firing charm tears, A fourth Ball of Bandages will make the Bandage Girl bigger and stronger, making her deal 5.5 damage per tick instead, Any further Ball of Bandages will repeat the cycle, Increases the chance of champion enemies appearing by 15%, Doesn't affect the chance for champion bosses to spawn, * shop room pool, shop item pool, red, croissant, crescent, Bombs now become poop bombs, which deal 10 damage to all enemies in the room and daze them for a short period of time, Butt Bombs heal the poop bosses (Dingle, Dangle, Brownie) by 25% of their max HP, * boss rush pool, boss rush room, item room, treasure room, item room pool, poop, face, brown, If Isaac stands still and stops shooting for a second, he turns to stone, making him invincible until he moves/shoots again, Using bombs or your active item will remove the invicibility as well, This item is a reference to the Tanuki suit in Super Mario 3, * item room, treasure room, item room pool, raccoon, green, Spawns 2-5 friendly attack spiders every time you take damage, REPENTANCE - Buffed, used to spawn 1-2 spiders, * item room, treasure room, item room pool, the lost item pool, purple, blue, heart, cute spider baby, When Isaac dies, he has a 50% chance to resurrect with 1/2 a heart, * curse room pool, red chest pool, red chest item pool, devil pool, devil room pool, devil deal, In Basement 2 tainted character and what makes them special them special how unlock... 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